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KMID : 0357920010350060486
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Korean Journal of Pathology
2001 Volume.35 No. 6 p.486 ~ p.495
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Expression of β-Catenin, c-Myc, and Cyclin D1 in Pulmonary Adenocarcinomas
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Chun Bong-Kwon
Yoon Hye-Kyoung
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Abstract
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Background: β-Catenin has dual functions: adhesive molucule and transcriptional activator. Subcellular accumulation of β-catenin and subsequent formation of β-catenin- Tcf/Lef-1 complexes, as well as c-myc and cyclin D1 genes which were recently defined as target genes of β-catenin- Tcf/Lef-1, has been shown to be important in the development of colorectal and breast carcinomas. The author investigated the rate of subcellular accumulation of β-catenin and overexpression of c-myc and cyclin D1, and also investigated the association between them in the pulmonary adenocarcinomas.
Methods: Fifty-one surgically resected primary adenocarcinomas of the lung, including 11 bronchioloalveolar carcinomas, were investigated by immunohistochemical analysis with monoclonal antibodies specific for β-catenin, c-myc and cyclin D1. Clinico-pathological information were collected from the patient charts and surgical pathology reports.
Results: Accumulation of β-catenin in the nucleus and/or cytoplasm and overexpression of c-myc and cyclin D1 were observed to be 20%, 37%, 16%, respectively. Ten cases showing accumulated patterns of β-catenin revealed alternative overexpressions of c-myc (7 cases) and cyclin D1 (3 cases). In nonmucinous tumors, 9 cases showing overexpression of c-myc or cyclin D1 revealed accumulations of β-catenin. The accumulation of β-catenin was not statistically related to clinico-pathological parameters. The association between c-myc overexpression and histological subtype of tumors was observed.
Conclusions: It is suggested that the accumulation of β-catenin is closely associated with tumorigenesis in a minor subset (20%) of peripheral adenocarcinomas of the lung. It is also suggested that transactivation of β-catenin may closely be associated with the overexpression of c-myc or cyclin D1 in the nonmucinous adenocarcinoma.
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KEYWORD
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Lung neoplasms Immunohistochemistry, Proto-oncogene proteins c-myc
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